FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth

FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth

Abstract Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor. FBXW7 is a highly mutated gene in CRC, but its biological functions in cancer are not fully characterized. Here, we report that FBXW7β, a FBXW7 isoform located in the cytoplasm and frequently mutated...

Full description

Bibliographic Details
Main Authors: Wenxia Wei, Baifu Qin, Weijie Wen, Boyu Zhang, Haidan Luo, Yuzhi Wang, Hui Xu, Xiaoshan Xie, Sicheng Liu, Xin Jiang, Mengan Wang, Qin Tang, Jiayu Zhang, Runxiang Yang, Zongmin Fan, Haiwen Lyu, Junzhong Lin, Kai Li, Mong-Hong Lee
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01405-8

Internet

https://doi.org/10.1038/s41392-023-01405-8

Similar Items