17-β Estradiol up-regulates energy metabolic pathways, cellular proliferation and tumor invasiveness in ER+ breast cancer spheroids

17-β Estradiol up-regulates energy metabolic pathways, cellular proliferation and tumor invasiveness in ER+ breast cancer spheroids

Several biological processes related to cancer malignancy are regulated by 17-β estradiol (E2) in ER+-breast cancer. To establish the role of E2 on the atypical cancer energy metabolism, a systematic study analyzing transcription factors, proteins, and fluxes associated with energy metabolism was un...

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Bibliographic Details
Main Authors: Silvia Cecilia Pacheco-Velázquez, Ingrid Itzayanna Ortega-Mejía, Jorge Luis Vargas-Navarro, Joaquín Alberto Padilla-Flores, Diana Xochiquetzal Robledo-Cadena, Gabriela Tapia-Martínez, Ignacio Peñalosa-Castro, José Luis Aguilar-Ponce, Juan Carlos Granados-Rivas, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
17-β estradiol
ER+ breast cancer
OxPhos
glycolysis
anti-mitochondrial therapy
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1018137/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1018137/full

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