Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy

Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy

Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library and kinase library were screened using the malachite green phosphate...

Full description

Bibliographic Details
Main Authors: Xin Pan, Teng-yu Mao, Yan-wen Mai, Cheng-cheng Liang, Wei-hao Huang, Yong Rao, Zhi-shu Huang, Shi-liang Huang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
HSP90 inhibitor
dual−target inhibitor
topo II inhibitor
quinacrine
the N−ATPase domains
Online Access:https://www.mdpi.com/1420-3049/27/17/5561

Internet

https://www.mdpi.com/1420-3049/27/17/5561

Similar Items