Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes
We have successfully developed curcumin nanosuspension intended for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers, including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carb...
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| Format: | Article |
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MDPI AG
2016-10-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | http://www.mdpi.com/2218-0532/84/4/685 |
| _version_ | 1811183889630101504 |
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| author | Heni Rachmawati Annisa Rahma Loaye Al Shaal Rainer H. Müller Cornelia M. Keck |
| author_facet | Heni Rachmawati Annisa Rahma Loaye Al Shaal Rainer H. Müller Cornelia M. Keck |
| author_sort | Heni Rachmawati |
| collection | DOAJ |
| description | We have successfully developed curcumin nanosuspension intended for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers, including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethylcellulose (Na-CMC), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), and sodium dodecyl sulfate (SDS). The average diameter of particles, microscopic appearance, and sedimentation of each preparation was observed and compared. Each stabilizer demonstrated a different degree of inhibition of particle aggregation under electrolyte-containing simulated gastrointestinal (GIT) fluid. Non-ionic stabilizers (PVA, PVP, and TPGS) were shown to preserve the nanosuspension stability against electrolytes. In contrast, strong ionic surfactants such as SDS were found to be very sensitive to electrolytes. The results can provide useful information for the formulators to choose the most suitable stabilizers by considering the nature of stabilizers and physiological characteristics of the target site of the drug. |
| first_indexed | 2024-04-11T13:05:24Z |
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| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-11T13:05:24Z |
| publishDate | 2016-10-01 |
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| series | Scientia Pharmaceutica |
| spelling | doaj.art-d5808e9d7c6d45969ff4663f7ec63d672022-12-22T04:22:49ZengMDPI AGScientia Pharmaceutica2218-05322016-10-0184468569310.3390/scipharm84040685scipharm84040685Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against ElectrolytesHeni Rachmawati0Annisa Rahma1Loaye Al Shaal2Rainer H. Müller3Cornelia M. Keck4Pharmaceutics Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, IndonesiaResearch Center for Nanosciences and Nanotechnology, Bandung Institute of Technology, Bandung 40132, IndonesiaDepartment of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin 12169, GermanyDepartment of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin 12169, GermanyDepartment of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin 12169, GermanyWe have successfully developed curcumin nanosuspension intended for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers, including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethylcellulose (Na-CMC), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), and sodium dodecyl sulfate (SDS). The average diameter of particles, microscopic appearance, and sedimentation of each preparation was observed and compared. Each stabilizer demonstrated a different degree of inhibition of particle aggregation under electrolyte-containing simulated gastrointestinal (GIT) fluid. Non-ionic stabilizers (PVA, PVP, and TPGS) were shown to preserve the nanosuspension stability against electrolytes. In contrast, strong ionic surfactants such as SDS were found to be very sensitive to electrolytes. The results can provide useful information for the formulators to choose the most suitable stabilizers by considering the nature of stabilizers and physiological characteristics of the target site of the drug.http://www.mdpi.com/2218-0532/84/4/685curcuminnanosuspensionelectrolyteparticle aggregationstabilizerionic surfactant |
| spellingShingle | Heni Rachmawati Annisa Rahma Loaye Al Shaal Rainer H. Müller Cornelia M. Keck Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes Scientia Pharmaceutica curcumin nanosuspension electrolyte particle aggregation stabilizer ionic surfactant |
| title | Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes |
| title_full | Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes |
| title_fullStr | Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes |
| title_full_unstemmed | Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes |
| title_short | Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes |
| title_sort | destabilization mechanism of ionic surfactant on curcumin nanocrystal against electrolytes |
| topic | curcumin nanosuspension electrolyte particle aggregation stabilizer ionic surfactant |
| url | http://www.mdpi.com/2218-0532/84/4/685 |
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