HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury

HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury

Cellular metabolism is a critical regulator of macrophage effector function. Tissue-resident alveolar macrophages (TR-AMs) inhabit a unique niche marked by high oxygen and low glucose. We have recently shown that in contrast to bone marrow-derived macrophages (BMDMs), TR-AMs do not utilize glycolysi...

Full description

Bibliographic Details
Main Authors: Parker S Woods, Lucas M Kimmig, Kaitlyn A Sun, Angelo Y Meliton, Obada R Shamaa, Yufeng Tian, Rengül Cetin-Atalay, Willard W Sharp, Robert B Hamanaka, Gökhan M Mutlu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
macrophages
metabolism
HIF
ARDS
acute lung injury
Online Access:https://elifesciences.org/articles/77457

Internet

https://elifesciences.org/articles/77457

Similar Items