HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury
Cellular metabolism is a critical regulator of macrophage effector function. Tissue-resident alveolar macrophages (TR-AMs) inhabit a unique niche marked by high oxygen and low glucose. We have recently shown that in contrast to bone marrow-derived macrophages (BMDMs), TR-AMs do not utilize glycolysi...
Main Authors: | Parker S Woods, Lucas M Kimmig, Kaitlyn A Sun, Angelo Y Meliton, Obada R Shamaa, Yufeng Tian, Rengül Cetin-Atalay, Willard W Sharp, Robert B Hamanaka, Gökhan M Mutlu |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/77457 |
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