Identification of Niche-Specific Gene Signatures between Malignant Tumor Microenvironments by Integrating Single Cell and Spatial Transcriptomics Data

Identification of Niche-Specific Gene Signatures between Malignant Tumor Microenvironments by Integrating Single Cell and Spatial Transcriptomics Data

The tumor microenvironment significantly affects the transcriptomic states of tumor cells. Single-cell RNA sequencing (scRNA-seq) helps elucidate the transcriptomes of individual cancer cells and their neighboring cells. However, cell dissociation results in the loss of information on neighboring ce...

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Bibliographic Details
Main Authors: Jahanzeb Saqib, Beomsu Park, Yunjung Jin, Junseo Seo, Jaewoo Mo, Junil Kim
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Genes
Subjects:
single-cell RNA sequencing
spatial transcriptomics
tumor microenvironments
data integration
niche-specific genes
spatial correlation
Online Access:https://www.mdpi.com/2073-4425/14/11/2033

Internet

https://www.mdpi.com/2073-4425/14/11/2033

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