Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy

Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy

This study aimed to investigate the anti-neuropathic pain activity and its underlying molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The rats were given a single injection of 60 mg/kg of streptozotocin (STZ) intraperitoneally (i.p.) to induce diabetic neuropat...

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Bibliographic Details
Main Authors: Adnan Khan, Feng Wang, Bushra Shal, Ashraf Ullah Khan, Syeda Saniya Zahra, Ihsan ul Haq, Salman Khan, Kannan RR Rengasamy
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Pharmacological Research
Subjects:
Diabetic neuropathy
Healthy lives
Medical
Streptozotocin
Ajugarin-I
Nrf2/Keap1
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822003371

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http://www.sciencedirect.com/science/article/pii/S1043661822003371

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