A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene. Subsequent sub-functionalization established subordination: Bub1, recruited first to kinetochores, promotes...

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Bibliographic Details
Main Authors: Katharina Overlack, Ivana Primorac, Mathijs Vleugel, Veronica Krenn, Stefano Maffini, Ingrid Hoffmann, Geert J P L Kops, Andrea Musacchio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-01-01
Series:eLife
Subjects:
cell division
centromere
kinetochore
spindle assembly checkpoint
cell cycle
Online Access:https://elifesciences.org/articles/05269

Internet

https://elifesciences.org/articles/05269

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