Neuroprotective effects of vinpocetine, as a phosphodiesterase 1 inhibitor, on long-term potentiation in a rat model of Alzheimer’s disease

Neuroprotective effects of vinpocetine, as a phosphodiesterase 1 inhibitor, on long-term potentiation in a rat model of Alzheimer’s disease

Abstract Background Vinpocetine (Vin) is known as a phosphodiesterase 1 inhibitor (PDE1-I) drug with multilateral effects, including antioxidant and anti-inflammatory activity. In this research, we investigated the neuroprotective and therapeutic effects of Vin through hippocampal synaptic plasticit...

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Bibliographic Details
Main Authors: Meysam Shekarian, Iraj Salehi, Safoura Raoufi, Masoumeh Asadbegi, Masoumeh Kourosh-Arami, Alireza Komaki
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Neuroscience
Subjects:
Alzheimer’s disease
Beta-amyloid
Vinpocetine
Phosphodiesterase1 inhibitor
Hippocampus
Long-term potentiation
Online Access:https://doi.org/10.1186/s12868-023-00790-8

Internet

https://doi.org/10.1186/s12868-023-00790-8

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