Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia

Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia

Background Circadian rhythm disorders, often seen in modern lifestyles, are a major social health concern. The aim of this study was to examine whether circadian rhythm disorders would influence angiogenesis and blood perfusion recovery in a mouse model of hind limb ischemia. Methods and Results A j...

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Bibliographic Details
Main Authors: Kazuhito Tsuzuki, Yuuki Shimizu, Junya Suzuki, Zhongyue Pu, Shukuro Yamaguchi, Yusuke Fujikawa, Katsuhiro Kato, Koji Ohashi, Mikito Takefuji, Yasuko K. Bando, Noriyuki Ouchi, John W. Calvert, Rei Shibata, Toyoaki Murohara
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiogenesis
circadian rhythm
cryptochrome
endothelial progenitor cell
hind limb ischemia
vascular endothelial growth factor
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.020896

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https://www.ahajournals.org/doi/10.1161/JAHA.121.020896

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