LOXL2 silencing suppresses angiotensin II-induced cardiac hypertrophy through the EMT process and TGF-β1/Smad3/NF-κB pathway

Objective(s): Atrial fibrillation (AF) is a common arrhythmia with atrial myocyte hypertrophy linked with stroke, heart failure, and increased mortality. Lysyl oxidase-like 2 (LOXL2) involves the cross-linking of collagen in the extracellular matrix (ECM). In the present study, we investigated the r...

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Bibliographic Details
Main Authors: Jun Luo, Yingbiao Wu, Xi Zhu, Saihua Wang, Xiaogang Zhang, Zhongping Ning
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-08-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:https://ijbms.mums.ac.ir/article_20824_407393c518ef38f9c211c447e09495be.pdf