Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model

Abstract Intravenous infusion of stem cells is a minimally invasive cellular delivery method, though a few have been reported in a critical limb-threatening ischemia (CLTI) animal model or patients. In the present study, we hypothesized that intravenous infusion of bone-marrow derived mesenchymal st...

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Bibliographic Details
Main Authors: Shusaku Maeda, Takuji Kawamura, Masanori Sasaki, Kazuo Shimamura, Takashi Shibuya, Akima Harada, Osamu Honmou, Yoshiki Sawa, Shigeru Miyagawa
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18485-1