Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia

Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia

Abstract Background Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered regulation of DNA methylation is an important epigenetic driver of AML, where the hypoxic bone marrow microenvironment can h...

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Bibliographic Details
Main Authors: Sam Humphries, Danielle R. Bond, Zacary P. Germon, Simon Keely, Anoop K. Enjeti, Matthew D. Dun, Heather J. Lee
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Hypoxia
Acute myeloid leukaemia
Epigenetics
Reactive oxygen species
Treatment outcomes
Online Access:https://doi.org/10.1186/s13148-023-01566-x

Internet

https://doi.org/10.1186/s13148-023-01566-x

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