Cationic Hydroxyethyl Cellulose Nanocomplexes and RANK siRNA/Zoledronate Co-Delivery Systems for Osteoclast Inhibition

Cationic Hydroxyethyl Cellulose Nanocomplexes and RANK siRNA/Zoledronate Co-Delivery Systems for Osteoclast Inhibition

Background/Objectives: In this study, HECP2k polymer, polyethylenimine2k (PEI2k)-modified hydroxyethyl cellulose (HEC) was utilized to form the nanocomplexes with receptor activator of nuclear factor k-B (RANK) siRNA and zoledronate (Zol) for osteoclast inhibition. HECP2k/(RANK siRNA + Zol) nanocomp...

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Bibliographic Details
Main Authors: Sohyun Lee, Seoyeon Park, Tae-il Kim
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
hydroxyethyl cellulose
nanocomplex
RANK siRNA
zoledronate
drug/gene co-delivery systems
osteoclast inhibition
Online Access:https://www.mdpi.com/1999-4923/16/12/1623

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https://www.mdpi.com/1999-4923/16/12/1623

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