3D Telomere Structure Analysis to Detect Genomic Instability and Cytogenetic Evolution in Myelodysplastic Syndromes

3D Telomere Structure Analysis to Detect Genomic Instability and Cytogenetic Evolution in Myelodysplastic Syndromes

The disease course of myelodysplastic syndromes (MDS) features chromosome instability and clonal evolution, leading to the sequential acquisition of novel cytogenetic aberrations and the accumulation of these abnormalities in the bone marrow. Although clonal cytogenetic abnormalities can be detected...

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Bibliographic Details
Main Authors: Aline Rangel-Pozzo, Daiane Corrêa de Souza, Ana Teresa Schmid-Braz, Ana Paula de Azambuja, Thais Ferraz-Aguiar, Tamara Borgonovo, Sabine Mai
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
myelodysplastic syndrome
cytogenetic evolution
genomic instability
3D nuclear telomere organization
Online Access:https://www.mdpi.com/2073-4409/8/4/304

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https://www.mdpi.com/2073-4409/8/4/304

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