Alpinetin Suppresses Effects of TGF-β1 on Stimulating the Production and Organization of Fibrotic Markers in Human Primary Dermal Fibroblasts

Alpinetin Suppresses Effects of TGF-β1 on Stimulating the Production and Organization of Fibrotic Markers in Human Primary Dermal Fibroblasts

Overgrowths of dermal fibroblasts and myofibroblast phenoconversion in response to TGF-β stimulation are the hallmarks of skin fibrosis. Constitutive activation of dermal fibroblasts by TGF-β induces the excessive production of extracellular matrix as well as certain key intracellular proteins which...

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Bibliographic Details
Main Authors: Nitwara Wikan, Saranyapin Potikanond, Wutigri Nimlamool
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
skin fibrosis
dermal fibroblasts
TGF-β1
myofibroblasts
alpinetin
mesenchymal features
Online Access:https://www.mdpi.com/2073-4409/11/17/2731

Internet

https://www.mdpi.com/2073-4409/11/17/2731

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