Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions.

Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions.

Calcium ions bind at the gating ring which triggers the gating of BK channels. However, the allosteric mechanism by which Ca2+ regulates the gating of BK channels remains obscure. Here, we applied Molecular Dynamics (MD) and Targeted MD to the integrated gating ring of BK channels, and achieved the...

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Bibliographic Details
Main Authors: Ronghua Guan, Hui Zhou, Junwei Li, Shaoying Xiao, Chunli Pang, Yafei Chen, Xiangrong Du, Shaoxi Ke, Qiongyao Tang, Jiguo Su, Yong Zhan, Hailong An
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5617150?pdf=render

Internet

http://europepmc.org/articles/PMC5617150?pdf=render

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