Unexpected Dynamic Binding May Rescue the Binding Affinity of Rivaroxaban in a Mutant of Coagulation Factor X

Unexpected Dynamic Binding May Rescue the Binding Affinity of Rivaroxaban in a Mutant of Coagulation Factor X

A novel coagulation factor X (FX) Tyr319Cys mutation (Y99C as chymotrypsin numbering) was identified in a patient with severe bleeding. Unlike the earlier reported Y99A mutant, this mutant can bind and cleave its specific chromogenetic substrate at a normal level, suggesting an intact binding pocket...

Full description

Bibliographic Details
Main Authors: Zhi-Li Zhang, Changming Chen, Si-Ying Qu, Qiulan Ding, Qin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
coagulation factors
rivaroxaban
molecular dynamics simulations
molecular flexibility
structure-based drug design
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.877170/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.877170/full

Similar Items