Targeted RNA N6‐Methyladenosine Demethylation Controls Cell Fate Transition in Human Pluripotent Stem Cells

Targeted RNA N6‐Methyladenosine Demethylation Controls Cell Fate Transition in Human Pluripotent Stem Cells

Abstract Deficiency of the N6‐methyladenosine (m6A) methyltransferase complex results in global reduction of m6A abundance and defective cell development in embryonic stem cells (ESCs). However, it's unclear whether regional m6A methylation affects cell fate decisions due to the inability to mo...

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Bibliographic Details
Main Authors: Xuena Chen, Qingquan Zhao, Yu‐Li Zhao, Guo‐Shi Chai, Weisheng Cheng, Zhiju Zhao, Jia Wang, Guan‐Zheng Luo, Nan Cao
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Advanced Science
Subjects:
ALKBH5
CRISPR
differentiation
m6A RNA modification
pluripotent stem cells
Online Access:https://doi.org/10.1002/advs.202003902

Internet

https://doi.org/10.1002/advs.202003902

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