Inhibition of inflammatory liver injury by the HMGB1-A box through HMGB1/TLR-4/NF-κB signaling in an acute liver failure mouse model

Inhibition of inflammatory liver injury by the HMGB1-A box through HMGB1/TLR-4/NF-κB signaling in an acute liver failure mouse model

We aimed to investigate the preventive effect of high mobility group box 1 (HMGB1)-A box and the mechanism by which it alleviates inflammatory injury in acute liver failure (ALF) by inhibiting the extracellular release of HMGB1. BALB/c mice were intraperitoneally (i.p.) administered LPS/D-GalN to es...

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Bibliographic Details
Main Authors: Lidan Luo, Shuai Wang, Bohao Chen, Mei Zhong, Ruili Du, ChunShan Wei, Furong Huang, Xinhui Kou, Yufeng Xing, Guangdong Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
acute liver failure
HMGB1-A box
TLR-4/NF-κB signaling
extracellular HMGB1
inflammatory injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.990087/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.990087/full

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