Activating Mutations and/or Expression Levels of Tyrosine Kinase Receptors GRB7, RAS, and BRAF in Testicular Germ Cell Tumors

Activating Mutations and/or Expression Levels of Tyrosine Kinase Receptors GRB7, RAS, and BRAF in Testicular Germ Cell Tumors

Amplification and/or overexpression of genes encoding tyrosine kinase receptors KIT and ERBB2 have been reported in testicular germ cell tumors (TGCTs). These receptors can bind the adaptor molecule GRB7 encoded by a gene adjacent to ERBB2 at 17q12, a region also frequently gained in TGCTs. GRB7 bin...

Full description

Bibliographic Details
Main Authors: Alan McIntyre, Brenda Summersgill, Hayley E. Spendlove, Robert Huddart, Richard Houlston, Janet Shipley
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TGCT
RAS
GRB7
ERBB2
BRAF
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800405

Internet

http://www.sciencedirect.com/science/article/pii/S1476558605800405

Similar Items