Impact of LKB1 status on radiation outcome in patients with stage III non-small-cell lung cancer

Impact of LKB1 status on radiation outcome in patients with stage III non-small-cell lung cancer

Abstract Preclinical studies suggest that loss of LKB1 expression renders cancer cells less responsive to radiation partly through NRF2-mediated upregulation of antioxidant enzymes protecting against radiation-induced DNA damage. Here we investigated the association of an alteration in this pathway...

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Bibliographic Details
Main Authors: Piyada Sitthideatphaiboon, Chonnipa Nantavithya, Poonchavist Chantranuwat, Chanida Vinayanuwattikun, Virote Sriuranpong
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Non-small cell lung cancer
Liver kinase B1
Nuclear factor erythroid 2-like 2
Locoregional recurrence
Radiotherapy
Online Access:https://doi.org/10.1038/s41598-024-55476-w

Internet

https://doi.org/10.1038/s41598-024-55476-w

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