Iterative design of training data to control intricate enzymatic reaction networks

Abstract Kinetic modeling of in vitro enzymatic reaction networks is vital to understand and control the complex behaviors emerging from the nonlinear interactions inside. However, modeling is severely hampered by the lack of training data. Here, we introduce a methodology that combines an active le...

Full description

Bibliographic Details
Main Authors: Bob van Sluijs, Tao Zhou, Britta Helwig, Mathieu G. Baltussen, Frank H. T. Nelissen, Hans A. Heus, Wilhelm T. S. Huck
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45886-9