Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq

Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq

Abstract Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. Self-reactivity may lead to negative selection, or to agonist selection and differentiation into unconventional lin...

Full description

Bibliographic Details
Main Authors: Marte Heimli, Siri Tennebø Flåm, Hanne Sagsveen Hjorthaug, Pål Marius Bjørnstad, Maria Chernigovskaya, Quy Khang Le, Xavier Tekpli, Victor Greiff, Benedicte Alexandra Lie
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44693-4

Internet

https://doi.org/10.1038/s41598-023-44693-4

Similar Items