Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway
Chondrosarcoma is a malignant bone tumor that is characterized by high metastatic potential and marked resistance to radiation and chemotherapy. The knowledge that adipokines facilitate the initiation, progression, metastasis, and treatment resistance of various tumors has driven several in vitro an...
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2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| author | Shih-Ya Hung Chih-Yang Lin Cheng-Chieh Yu Hsien-Te Chen Ming-Yu Lien Yu-Wen Huang Yi-Chin Fong Ju-Fang Liu Shih-Wei Wang Wei-Cheng Chen Chih-Hsin Tang |
| author_facet | Shih-Ya Hung Chih-Yang Lin Cheng-Chieh Yu Hsien-Te Chen Ming-Yu Lien Yu-Wen Huang Yi-Chin Fong Ju-Fang Liu Shih-Wei Wang Wei-Cheng Chen Chih-Hsin Tang |
| author_sort | Shih-Ya Hung |
| collection | DOAJ |
| description | Chondrosarcoma is a malignant bone tumor that is characterized by high metastatic potential and marked resistance to radiation and chemotherapy. The knowledge that adipokines facilitate the initiation, progression, metastasis, and treatment resistance of various tumors has driven several in vitro and in vivo investigations into the effects of adipokines resistin, leptin, and adiponectin upon the development and progression of chondrosarcomas. Another adipokine, visfatin, is known to regulate tumor progression and metastasis, although how this molecule may affect chondrosarcoma metastasis is unclear. Here, we found that visfatin facilitated cellular migration via matrix metalloproteinase-2 (MMP-2) production in human chondrosarcoma cells and overexpression of visfatin enhanced lung metastasis in a mouse model of chondrosarcoma. Visfatin-induced stimulation of MMP-2 synthesis and activation of the AP-1 transcription factor facilitated chondrosarcoma cell migration via the ERK, p38, and JNK signaling pathways. This evidence suggests that visfatin is worth targeting in the treatment of metastatic chondrosarcoma. |
| first_indexed | 2024-03-10T08:45:12Z |
| format | Article |
| id | doaj.art-d5a97c6fe4424c5a9ae8ade1dd573936 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:45:12Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d5a97c6fe4424c5a9ae8ade1dd5739362023-11-22T07:58:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216864210.3390/ijms22168642Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK PathwayShih-Ya Hung0Chih-Yang Lin1Cheng-Chieh Yu2Hsien-Te Chen3Ming-Yu Lien4Yu-Wen Huang5Yi-Chin Fong6Ju-Fang Liu7Shih-Wei Wang8Wei-Cheng Chen9Chih-Hsin Tang10Graduate Institute of Acupuncture Science, China Medical University, Taichung 404022, TaiwanDepartment of Pharmacology, School of Medicine, China Medical University, Taichung 404022, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404022, TaiwanDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung 404022, TaiwanDivision of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 404022, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404022, TaiwanDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung 404022, TaiwanSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110301, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 252005, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 252005, TaiwanDepartment of Pharmacology, School of Medicine, China Medical University, Taichung 404022, TaiwanChondrosarcoma is a malignant bone tumor that is characterized by high metastatic potential and marked resistance to radiation and chemotherapy. The knowledge that adipokines facilitate the initiation, progression, metastasis, and treatment resistance of various tumors has driven several in vitro and in vivo investigations into the effects of adipokines resistin, leptin, and adiponectin upon the development and progression of chondrosarcomas. Another adipokine, visfatin, is known to regulate tumor progression and metastasis, although how this molecule may affect chondrosarcoma metastasis is unclear. Here, we found that visfatin facilitated cellular migration via matrix metalloproteinase-2 (MMP-2) production in human chondrosarcoma cells and overexpression of visfatin enhanced lung metastasis in a mouse model of chondrosarcoma. Visfatin-induced stimulation of MMP-2 synthesis and activation of the AP-1 transcription factor facilitated chondrosarcoma cell migration via the ERK, p38, and JNK signaling pathways. This evidence suggests that visfatin is worth targeting in the treatment of metastatic chondrosarcoma.https://www.mdpi.com/1422-0067/22/16/8642visfatinchondrosarcomametastasismatrix metalloproteinase-2AP-1 |
| spellingShingle | Shih-Ya Hung Chih-Yang Lin Cheng-Chieh Yu Hsien-Te Chen Ming-Yu Lien Yu-Wen Huang Yi-Chin Fong Ju-Fang Liu Shih-Wei Wang Wei-Cheng Chen Chih-Hsin Tang Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway International Journal of Molecular Sciences visfatin chondrosarcoma metastasis matrix metalloproteinase-2 AP-1 |
| title | Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway |
| title_full | Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway |
| title_fullStr | Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway |
| title_full_unstemmed | Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway |
| title_short | Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway |
| title_sort | visfatin promotes the metastatic potential of chondrosarcoma cells by stimulating ap 1 dependent mmp 2 production in the mapk pathway |
| topic | visfatin chondrosarcoma metastasis matrix metalloproteinase-2 AP-1 |
| url | https://www.mdpi.com/1422-0067/22/16/8642 |
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