Frequency of Hereditary Hemochromatosis Gene (HFE) Variants in Sri Lankan Transfusion-Dependent Beta-Thalassemia Patients and Their Association With the Serum Ferritin Level

Frequency of Hereditary Hemochromatosis Gene (HFE) Variants in Sri Lankan Transfusion-Dependent Beta-Thalassemia Patients and Their Association With the Serum Ferritin Level

IntroductionCo-inheritance of hereditary hemochromatosis (HFE) gene variants p. C282Y and p.H63D worsen iron overload in transfusion-dependent thalassemia. Data on the HFE gene variants in Sri Lankan patients with thalassemia have not been extensively studied. This study aimed to analyze the p.C282Y...

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Bibliographic Details
Main Authors: Padmapani Padeniya, Hemali Goonasekara, Gayan Abeysekera, Rohan Jayasekara, Vajira Dissanayake
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pediatrics
Subjects:
transfusion dependent thalassemia
c.845G>A
c.187C>G
ferritin
ARMS-PCR
hereditary hemochromatosis
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.890989/full

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https://www.frontiersin.org/articles/10.3389/fped.2022.890989/full

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