Frequency of Hereditary Hemochromatosis Gene (HFE) Variants in Sri Lankan Transfusion-Dependent Beta-Thalassemia Patients and Their Association With the Serum Ferritin Level

Frequency of Hereditary Hemochromatosis Gene (HFE) Variants in Sri Lankan Transfusion-Dependent Beta-Thalassemia Patients and Their Association With the Serum Ferritin Level

IntroductionCo-inheritance of hereditary hemochromatosis (HFE) gene variants p. C282Y and p.H63D worsen iron overload in transfusion-dependent thalassemia. Data on the HFE gene variants in Sri Lankan patients with thalassemia have not been extensively studied. This study aimed to analyze the p.C282Y...

Full description

Bibliographic Details
Main Authors: Padmapani Padeniya, Hemali Goonasekara, Gayan Abeysekera, Rohan Jayasekara, Vajira Dissanayake
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pediatrics
Subjects:
transfusion dependent thalassemia
c.845G>A
c.187C>G
ferritin
ARMS-PCR
hereditary hemochromatosis
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.890989/full

Similar Items

Similar Items