Modeling Parkinson’s Disease With the Alpha-Synuclein Protein

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein

Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars compacta and the abnormal accumulation and aggregation of α-Syn in the form of Lewy bodies and Lewy neurites. More...

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Bibliographic Details
Main Authors: Mónica Gómez-Benito, Noelia Granado, Patricia García-Sanz, Anne Michel, Mireille Dumoulin, Rosario Moratalla
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
Lewy body pathology
α-Syn pre-formed fibrils
α-Syn AVV-viral particles
prion-like propagation
Braak hypothesis
α-Syn aggregation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00356/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00356/full

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