Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via cAMP-PKA-CREB pathway in vitro

Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via cAMP-PKA-CREB pathway in vitro

Abstract Background Genetic causes of premature ovarian insufficiency (POI) account for approximately 20 ~ 25% of patients. So far, only a few genes have been identified. Results Here, we first identified the c.1840C > A on G-protein signaling modulator 1 (GPSM1) as a susceptibility locus for POI...

Full description

Bibliographic Details
Main Authors: Xuzi Cai, Huijiao Fu, Yan Wang, Qiwen Liu, Xuefeng Wang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Ovarian Research
Subjects:
Premature ovarian insufficiency
Whole-exome sequencing
GPSM1
Ovarian granulosa cell
cAMP-PKA-CREB pathway
Online Access:http://link.springer.com/article/10.1186/s13048-020-00740-6

Internet

http://link.springer.com/article/10.1186/s13048-020-00740-6

Similar Items