Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

This study aimed to develop a practical semi-mechanistic modeling framework to predict particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a wide range of process conditions and milling scales. The model incorporates process parameters, formulation parameters, and...

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Bibliographic Details
Main Authors: Donald J. Clancy, Gulenay Guner, Sayantan Chattoraj, Helen Yao, M. Connor Faith, Zahra Salahshoor, Kailey N. Martin, Ecevit Bilgili
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Pharmaceutics
Subjects:
milling
wet bead milling
particle size prediction
modeling
semi-mechanistic modeling
microhydrodynamic model
Online Access:https://www.mdpi.com/1999-4923/16/3/394

Internet

https://www.mdpi.com/1999-4923/16/3/394

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