Mitochondrial heteroplasmy profiling in single human oocytes by next-generation sequencing

Mitochondrial heteroplasmy profiling in single human oocytes by next-generation sequencing

Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. Mutations of the mitochondrial genome lead to an altered energetic metabolism with negative effects on oocyte developmental competence. In this study, mtDNA heteroplasmy at an intra-oocyte level and between the diff...

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Bibliographic Details
Main Authors: Massimo Ancora, Massimiliano Orsini, Alessia Colosimo, Valentina Russo, Maurilia Marcacci, Maria De Santo, Marco D’Aurora, Liborio Stuppia, Valentina Gatta, Barbara Barboni, Cesare Cammà, Mauro Mattioli
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:Mitochondrial DNA. Part B. Resources
Subjects:
heteroplasmic mutations
human oocyte
mitochondrial dna
next-generation sequencing
Online Access:http://dx.doi.org/10.1080/23802359.2017.1365634

Internet

http://dx.doi.org/10.1080/23802359.2017.1365634

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