Novel Purine Derivative ITH15004 Facilitates Exocytosis through a Mitochondrial Calcium-Mediated Mechanism

Novel Purine Derivative ITH15004 Facilitates Exocytosis through a Mitochondrial Calcium-Mediated Mechanism

Upon depolarization of chromaffin cells (CCs), a prompt release of catecholamines occurs. This event is triggered by a subplasmalemmal high-Ca<sup>2+</sup> microdomain (HCMD) generated by Ca<sup>2+</sup> entry through nearby voltage-activated calcium channels. HCMD is efficie...

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Bibliographic Details
Main Authors: Ricardo de Pascual, Francesco Calzaferri, Paula C. Gonzalo, Rubén Serrano-Nieto, Cristóbal de los Ríos, Antonio G. García, Luis Gandía
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
ITH15004
chromaffin cell
catecholamine release
calcium signalling
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/23/1/440

Internet

https://www.mdpi.com/1422-0067/23/1/440

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