Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

Abstract Background Hepatocellular carcinoma (HCC) is the one of the most common cancers and lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and may play important roles in carcinogenesis and diagnosis. Methods Using the TCGA HCC dataset, we classified HCC pati...

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Bibliographic Details
Main Authors: Jinming Cheng, Dongkai Wei, Yuan Ji, Lingli Chen, Liguang Yang, Guang Li, Leilei Wu, Ting Hou, Lu Xie, Guohui Ding, Hong Li, Yixue Li
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Genome Medicine
Subjects:
Hepatocellular carcinoma
Methylation
CpG island methylator phenotype
Gene regulation
Specific diagnostic biomarker
Online Access:http://link.springer.com/article/10.1186/s13073-018-0548-z

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http://link.springer.com/article/10.1186/s13073-018-0548-z

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