Random-PE: an efficient integration of random sequences into mammalian genome by prime editing

Random-PE: an efficient integration of random sequences into mammalian genome by prime editing

Abstract Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks or donor templates. Here we designed a simple strategy to introduce random DNA sequences into targeted genomic loci by prime editing, which we...

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Bibliographic Details
Main Authors: Yaoge Jiao, Lifang Zhou, Rui Tao, Yanhong Wang, Yun Hu, Lurong Jiang, Li Li, Shaohua Yao
Format: Article
Language:English
Published: Springer 2021-11-01
Series:Molecular Biomedicine
Subjects:
CRISPR/Cas9
Prime editing
Random sequence
Gene evolution
Online Access:https://doi.org/10.1186/s43556-021-00057-w

Internet

https://doi.org/10.1186/s43556-021-00057-w

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