Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca2+-sensitisation

Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca2+-sensitisation

Abstract Background PDGFR-inhibition by the tyrosine kinase inhibitor (TKI) nintedanib attenuates the progress of idiopathic pulmonary fibrosis (IPF). However, the effects of PDGF-BB on the airway tone are almost unknown. We studied this issue and the mechanisms beyond, using isolated perfused lungs...

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Bibliographic Details
Main Authors: Annette D. Rieg, Said Suleiman, Carolin Anker, Nina A. Bünting, Eva Verjans, Jan Spillner, Sebastian Kalverkamp, Saskia von Stillfried, Till Braunschweig, Stefan Uhlig, Christian Martin
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Respiratory Research
Online Access:https://doi.org/10.1186/s12931-022-02101-x

Internet

https://doi.org/10.1186/s12931-022-02101-x

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