Withaferin A Enhances Mitochondrial Biogenesis and BNIP3-Mediated Mitophagy to Promote Rapid Adaptation to Extreme Hypoxia

Withaferin A Enhances Mitochondrial Biogenesis and BNIP3-Mediated Mitophagy to Promote Rapid Adaptation to Extreme Hypoxia

Rapid adaptation to extreme hypoxia is a challenging problem, and there is no effective scheme to achieve rapid adaptation to extreme hypoxia. In this study, we found that withaferin A (WA) can significantly reduce myocardial damage, maintain cardiac function, and improve survival in rats in extreme...

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Bibliographic Details
Main Authors: Ruzhou Zhao, Yixin Xu, Xiaobo Wang, Xiang Zhou, Yanqi Liu, Shuai Jiang, Lin Zhang, Zhibin Yu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
withaferin A
PGC-1α
BNIP3
mitochondrial biogenesis
mitophagy
Online Access:https://www.mdpi.com/2073-4409/12/1/85

Internet

https://www.mdpi.com/2073-4409/12/1/85

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