Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Selective Vascular Endothelial Growth Factor Promoter i-Motif Ligands

Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Selective Vascular Endothelial Growth Factor Promoter i-Motif Ligands

Vascular endothelial growth factor (VEGF) is an angiogenic growth factor and plays a key role in tumor progression. The C-rich DNA sequence of <i>VEGF</i> promoter can form i-motif structure, which is a potential target for the development of novel anticancer agents. However, there is a...

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Bibliographic Details
Main Authors: Huang Zeng, Shuangshuang Kang, Yu Zhang, Ke Liu, Qian Yu, Ding Li, Lin-Kun An
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
vascular endothelial growth factor
oleanolic acid
i-motif
gene transcriptional regulation
antiproliferation
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/4/1711

Internet

https://www.mdpi.com/1422-0067/22/4/1711

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