High Energy Channeling and Malleable Transition States: Molecular Dynamics Simulations and Free Energy Landscapes for the Thermal Unfolding of Protein U1A and 13 Mutants

High Energy Channeling and Malleable Transition States: Molecular Dynamics Simulations and Free Energy Landscapes for the Thermal Unfolding of Protein U1A and 13 Mutants

The spliceosome protein U1A is a prototype case of the RNA recognition motif (RRM) ubiquitous in biological systems. The in vitro kinetics of the chemical denaturation of U1A indicate that the unfolding of U1A is a two-state process but takes place via high energy channeling and a malleable transiti...

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Bibliographic Details
Main Authors: Na Le Dang, Anne M. Baranger, David L. Beveridge
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomolecules
Subjects:
Molecular dynamics
protein unfolding
transition state
U1A
Online Access:https://www.mdpi.com/2218-273X/12/7/940

Internet

https://www.mdpi.com/2218-273X/12/7/940

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