Ceria-Zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular and animal models of Fabry disease

Ceria-Zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular and animal models of Fabry disease

Abstract Background Fabry disease (FD) is a lysosome storage disease (LSD) characterized by significantly reduced intracellular autophagy function. This contributes to the progression of intracellular pathologic signaling and can lead to organ injury. Phospholipid–polyethyleneglycol-capped Ceria-Zir...

Full description

Bibliographic Details
Main Authors: Jong Hun An, Sang-Eun Hong, Seong-Lan Yu, Jaeku Kang, Chang Gyo Park, Hoi Young Lee, Sung-Ki Lee, Dong Chul Lee, Hwan-Woo Park, Won-Min Hwang, Sung-Ro Yun, Yohan Park, Moon Hyang Park, Kuk Ro Yoon, Se-Hee Yoon
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
Ceria-Zirconia nanoparticle
Fabry disease
Autophagy flux
Globotriaosylceramide
Online Access:https://doi.org/10.1186/s12951-022-01318-8

Internet

https://doi.org/10.1186/s12951-022-01318-8

Similar Items