Loss of ATOH1 in Pit Cell Drives Stemness and Progression of Gastric Adenocarcinoma by Activating AKT/mTOR Signaling through GAS1

Loss of ATOH1 in Pit Cell Drives Stemness and Progression of Gastric Adenocarcinoma by Activating AKT/mTOR Signaling through GAS1

Abstract Gastric cancer stem cells (GCSCs) are self‐renewing tumor cells that govern chemoresistance in gastric adenocarcinoma (GAC), whereas their regulatory mechanisms remain elusive. Here, the study aims to elucidate the role of ATOH1 in the maintenance of GCSCs. The preclinical model and GAC sam...

Full description

Bibliographic Details
Main Authors: Qing Zhong, Hua‐Gen Wang, Ji‐Hong Yang, Ru‐Hong Tu, An‐Yao Li, Gui‐Rong Zeng, Qiao‐Ling Zheng, Zhi‐ Yu Liu, Zhi‐Xin Shang‐Guan, Xiao‐ Bo Huang, Qiang Huang, Yi‐Fan Li, Hua‐Long Zheng, Guang‐Tan Lin, Ze‐Ning Huang, Kai‐Xiang Xu, Wen‐Wu Qiu, Mei‐Chen Jiang, Ya‐Jun Zhao, Jian‐Xian Lin, Zhi‐Hong Huang, Jing‐Min Huang, Ping Li, Jian‐Wei Xie, Chao‐Hui Zheng, Qi‐Yue Chen, Chang‐Ming Huang
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
ATOH1
GAS1
gastric adenocarcinoma
mouse model
stemness
Online Access:https://doi.org/10.1002/advs.202301977

Internet

https://doi.org/10.1002/advs.202301977

Similar Items