TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma

TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma

Background Immunotherapy has facilitated great breakthroughs in the treatment of hepatocellular carcinoma (HCC). However, the efficacy and response rate of immunotherapy are limited and vary among different patients with HCC. TP53 mutation substantially affects the expression of immune checkpoint mo...

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Bibliographic Details
Main Authors: Tingting Feng, Wei Zhou, Lu Yin, Lin Zhou, Haiyang Xie, Shusen Zheng, Xiao Xu, Sunbin Ling, Qifan Zhan, Shengjun Xu, Kangchen Chen, Jimin Liu, Shuai Wang, Yuchen Liu, Xuyong Wei, Lincheng Zhang, Jiongjie Yu, Jiachen Hong, Qingyang Que, Yongfeng Wu, Jiaqi Bao, Nan Xu, Zhikun Liu
Format: Article
Language:English
Published: BMJ Publishing Group 2023-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/11/e007479.full

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https://jitc.bmj.com/content/11/11/e007479.full

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