Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies

Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies

Mutations in genes encoding molecular chaperones, for instance the genes encoding the subunits of the chaperonin CCT (chaperonin containing TCP-1, also known as TRiC), are associated with rare neurodegenerative disorders. Using a classical molecular dynamics approach, we investigated the occurrence...

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Bibliographic Details
Main Authors: Federica Scalia, Giosuè Lo Bosco, Letizia Paladino, Alessandra Maria Vitale, Leila Noori, Everly Conway de Macario, Alberto J. L. Macario, Fabio Bucchieri, Francesco Cappello, Fabrizio Lo Celso
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
chaperone system
CCT5
CCT5 mutations
CCT5 chaperonopathies
apical domain
hydrogen bonds
Online Access:https://www.mdpi.com/1422-0067/24/3/2018

Internet

https://www.mdpi.com/1422-0067/24/3/2018

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