Acquisition of pluripotency through continued environmental influence on OCT4-induced plastic human fibroblasts

Acquisition of pluripotency through continued environmental influence on OCT4-induced plastic human fibroblasts

The combination of OCT4 expression and short-term exposure to reprogramming media induces a state of transcriptional plasticity in human fibroblasts, capable of responding to changes in the extracellular environment that facilitate direct cell fate conversion toward lineage specific progenitors. Her...

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Bibliographic Details
Main Authors: Kyle R. Salci, Jung Bok Lee, Ryan R. Mitchell, Luca Orlando, Aline Fiebig-Comyn, Zoya Shapovalova, Mickie Bhatia
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506115000793

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http://www.sciencedirect.com/science/article/pii/S1873506115000793

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