Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade

Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade

Molecular determinants underlying interferon (IFN)-macrophage biology can help delineate enzyme systems, pathways and mechanisms for enabling host-directed therapeutic approaches against infection. Notably, while the IFN antiviral response is known to be directly coupled to mevalonate-sterol biosynt...

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Bibliographic Details
Main Authors: Widad Dantoft, Kevin A. Robertson, W. John Watkins, Birgit Strobl, Peter Ghazal
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
cholesterol
metabolism
lipid pathway
sterol
epigenetic
interferon
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00355/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00355/full

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