ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

Angiopoietin-like 4 (ANGPTL4) is an important regulator of plasma triglyceride (TG) levels and an attractive pharmacological target for lowering plasma lipids and reducing cardiovascular risk. Here, we aimed to study the efficacy and safety of silencing ANGPTL4 in the livers of mice using hepatocyte...

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Bibliographic Details
Main Authors: Mingjuan Deng, Elda Kutrolli, Anne Sadewasser, Sven Michel, Masoumeh Motamedi Joibari, Frank Jaschinski, Gunilla Olivecrona, Stefan K. Nilsson, Sander Kersten
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Journal of Lipid Research
Subjects:
adipose tissue
liver
lipase/lipoprotein
lipoproteins/metabolism
triglycerides
angiopoietin-like 4
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000700

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http://www.sciencedirect.com/science/article/pii/S0022227522000700

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