ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

Angiopoietin-like 4 (ANGPTL4) is an important regulator of plasma triglyceride (TG) levels and an attractive pharmacological target for lowering plasma lipids and reducing cardiovascular risk. Here, we aimed to study the efficacy and safety of silencing ANGPTL4 in the livers of mice using hepatocyte...

Full description

Bibliographic Details
Main Authors:	Mingjuan Deng, Elda Kutrolli, Anne Sadewasser, Sven Michel, Masoumeh Motamedi Joibari, Frank Jaschinski, Gunilla Olivecrona, Stefan K. Nilsson, Sander Kersten
Format:	Article
Language:	English
Published:	Elsevier 2022-07-01
Series:	Journal of Lipid Research
Subjects:	adipose tissue liver lipase/lipoprotein lipoproteins/metabolism triglycerides angiopoietin-like 4
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227522000700

Similar Items

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]
by: Yan Wang, et al.
Published: (2015-07-01)

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[S]
by: Antwi-Boasiako Oteng, et al.
Published: (2019-10-01)

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
by: Wieneke Dijk, et al.
Published: (2015-10-01)

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids[S]
by: Yan Q. Chen, et al.
Published: (2020-08-01)

Characterization of sexual dimorphism in ANGPTL4 levels and function
by: Mingjuan Deng, et al.
Published: (2024-04-01)

Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue
by: Philip M.M. Ruppert, et al.
Published: (2020-10-01)

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
by: Kelli L. Sylvers-Davie, et al.
Published: (2021-01-01)

A new enzyme-linked immunosorbent assay system for human serum hepatic triglyceride lipase
by: Kazuya Miyashita, et al.
Published: (2017-08-01)

A randomised, controlled, crossover study of the effect of diet on angiopoietin-like protein 4 (ANGPTL4) through modification of the gut microbiome
by: Trine Blædel, et al.
Published: (2016-01-01)

Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4
by: Fredrik Landfors, et al.
Published: (2023-01-01)

CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats
by: Ryota Izumi, et al.
Published: (2018-09-01)

ANGPTL3 Is Involved in the Post-prandial Response in Triglyceride-Rich Lipoproteins and HDL Components in Patients With Coronary Artery Disease
by: Xin Guo, et al.
Published: (2022-06-01)

Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase
by: Shi-Qin Xiang, et al.
Published: (1999-09-01)

Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues
by: Qiaoling Yao, et al.
Published: (2013-04-01)

Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits
by: William G. Hoffmann, et al.
Published: (2024-02-01)

Effects of cold exposure on heart clearing factor lipase and triglyceride utilization in the rat
by: M. Perenna Rogers, et al.
Published: (1974-05-01)

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking
by: Ren Zhang
Published: (2016-01-01)

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif
by: Deepa Balasubramaniam, et al.
Published: (2022-05-01)

Effect of an anti-lipoprotein lipase serum on plasma triglyceride removal
by: I P Kompiang, et al.
Published: (1976-09-01)

A role of apolipoprotein D in triglyceride metabolism[S]
by: German Perdomo, et al.
Published: (2010-06-01)

Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4−/−Gpihbp1−/− mice
by: Emily M. Cushing, et al.
Published: (2018-01-01)

Key Molecules of Triglycerides Pathway Metabolism Are Disturbed in Patients With Systemic Lupus Erythematosus
by: Juan Carlos Quevedo-Abeledo, et al.
Published: (2022-05-01)

Aging and plasma triglyceride metabolism
by: Kathryn M. Spitler, et al.
Published: (2020-08-01)

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S]
by: Jorge F. Haller, et al.
Published: (2017-06-01)

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S]
by: Viktoria Gusarova, et al.
Published: (2015-07-01)

Editorial: TRLs (triglycerides-rich lipoproteins): a new target for atherosclerosis
by: Mei Dong, et al.
Published: (2025-01-01)

Triglyceride-Rich Lipoproteins: Their Role in Atherosclerosis
by: Yulino Castillo-Núñez, et al.
Published: (2022-04-01)

A method for the determination of lipoprotein lipase in postheparin plasma and body tissues utilizing a triolein-coated Celite substrate
by: Israel Posner, et al.
Published: (1971-11-01)

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis
by: Padmini P.S.J. Khedoe, et al.
Published: (2015-01-01)

Human milk lipases. I. Serum-stimulated lipase
by: Olle Hernell, et al.
Published: (1974-07-01)

Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity
by: Alwin Kamermans, et al.
Published: (2019-05-01)

The influence of fasting/refeeding on the lipoprotein lipase activity of adipose tissue and muscle
by: L.M. Botion
Published: (2001-11-01)

Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry
by: Mart Reimund, et al.
Published: (2017-01-01)

Higher order lipase gene association with plasma triglycerides
by: Muredach P. Reilly, et al.
Published: (2005-09-01)

On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
by: Oleg Kovrov, et al.
Published: (2019-04-01)

Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma
by: John C. LaRosa, et al.
Published: (1972-05-01)

Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
by: Yongsoon Park, et al.
Published: (2003-03-01)

Mathematical Modelling of Material Transfer to High-Density Lipoprotein (HDL) upon Triglyceride Lipolysis by Lipoprotein Lipase: Relevance to Cardioprotective Role of HDL
by: Svetlana Schekatolina, et al.
Published: (2022-07-01)

Evidence for separate monoglyceride hydrolase and triglyceride lipase in post-heparin human plasma
by: Heiner Greten, et al.
Published: (1969-05-01)

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity
by: Kristian Kølby Kristensen, et al.
Published: (2021-07-01)