Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system

Refractory and relapsed leukemia is a major problem during cancer therapy, which is due to the aberrant activation of Wnt/β-catenin signaling pathway. Activation of this pathway is promoted by wingless (Wnt) proteins and induces co-activator β-catenin binding to lymphoid enhancer f...

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Bibliographic Details
Main Authors: K.A. Chuang, C.H. Lieu, W.J. Tsai, M.H. Wu, Y.C. Chen, J.F. Liao, C.C. Wang, Y.C. Kuo
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-10-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000003