A phylogenetic approach to study the evolution of somatic mutational processes in cancer
A method, PhyloSignare, is presented to infer mutational signatures along a tumour evolutionary tree and is used to analyse somatic genomic variations in 61 lung cancer patients, providing insights into tumour evolution.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03560-0 |
| _version_ | 1811227112971960320 |
|---|---|
| author | Sayaka Miura Tracy Vu Jiyeong Choi Jeffrey P. Townsend Sajjad Karim Sudhir Kumar |
| author_facet | Sayaka Miura Tracy Vu Jiyeong Choi Jeffrey P. Townsend Sajjad Karim Sudhir Kumar |
| author_sort | Sayaka Miura |
| collection | DOAJ |
| description | A method, PhyloSignare, is presented to infer mutational signatures along a tumour evolutionary tree and is used to analyse somatic genomic variations in 61 lung cancer patients, providing insights into tumour evolution. |
| first_indexed | 2024-04-12T09:36:02Z |
| format | Article |
| id | doaj.art-d5d4368a35e74f418b09bc109f1131fe |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-12T09:36:02Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-d5d4368a35e74f418b09bc109f1131fe2022-12-22T03:38:14ZengNature PortfolioCommunications Biology2399-36422022-06-015111110.1038/s42003-022-03560-0A phylogenetic approach to study the evolution of somatic mutational processes in cancerSayaka Miura0Tracy Vu1Jiyeong Choi2Jeffrey P. Townsend3Sajjad Karim4Sudhir Kumar5Institute for Genomics and Evolutionary Medicine, Temple UniversityInstitute for Genomics and Evolutionary Medicine, Temple UniversityInstitute for Genomics and Evolutionary Medicine, Temple UniversityProgram in Computational Biology and Bioinformatics, Yale UniversityCenter for Excellence in Genomic Medicine Research, King Abdulaziz UniversityInstitute for Genomics and Evolutionary Medicine, Temple UniversityA method, PhyloSignare, is presented to infer mutational signatures along a tumour evolutionary tree and is used to analyse somatic genomic variations in 61 lung cancer patients, providing insights into tumour evolution.https://doi.org/10.1038/s42003-022-03560-0 |
| spellingShingle | Sayaka Miura Tracy Vu Jiyeong Choi Jeffrey P. Townsend Sajjad Karim Sudhir Kumar A phylogenetic approach to study the evolution of somatic mutational processes in cancer Communications Biology |
| title | A phylogenetic approach to study the evolution of somatic mutational processes in cancer |
| title_full | A phylogenetic approach to study the evolution of somatic mutational processes in cancer |
| title_fullStr | A phylogenetic approach to study the evolution of somatic mutational processes in cancer |
| title_full_unstemmed | A phylogenetic approach to study the evolution of somatic mutational processes in cancer |
| title_short | A phylogenetic approach to study the evolution of somatic mutational processes in cancer |
| title_sort | phylogenetic approach to study the evolution of somatic mutational processes in cancer |
| url | https://doi.org/10.1038/s42003-022-03560-0 |
| work_keys_str_mv | AT sayakamiura aphylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT tracyvu aphylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT jiyeongchoi aphylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT jeffreyptownsend aphylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT sajjadkarim aphylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT sudhirkumar aphylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT sayakamiura phylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT tracyvu phylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT jiyeongchoi phylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT jeffreyptownsend phylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT sajjadkarim phylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer AT sudhirkumar phylogeneticapproachtostudytheevolutionofsomaticmutationalprocessesincancer |