METTL3-Mediated N6-Methyladenosine Modification of Trim59 mRNA Protects Against Sepsis-Induced Acute Respiratory Distress Syndrome

METTL3-Mediated N6-Methyladenosine Modification of Trim59 mRNA Protects Against Sepsis-Induced Acute Respiratory Distress Syndrome

N6-methyladenosine (m6A) RNA modification is a fundamental determinant of mRNA metabolism in eukaryotic cells and is involved in numerous physiological and pathological processes. However, the specific role of m6A modification in sepsis-induced acute respiratory distress syndrome(ARDS) remains unkno...

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Bibliographic Details
Main Authors: Yi Chen, Yuling Wu, Linjie Zhu, Caiyang Chen, Saihong Xu, Dan Tang, Yingfu Jiao, Weifeng Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
sepsis
acute lung injury
endothelial barrier
epigenetic regulation
m6A
METTL3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.897487/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.897487/full

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